Alicia N. Lyle, PhD

Assistant Professor of Medicine

Emory University School of Medicine

Office: Woodruff Memorial Research Building, 3rd Floor

Phone: 404-727-8556

Fax: 404-727-3585

Email: alicia.lyle@emory.edu

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Biography

Dr. Alicia Lyle is an Assistant Professor of Medicine in the Division of Cardiology. She received her PhD in Pharmacology from Emory University in 2009, where she worked with Kathy K. Griendling, PhD. During this time, Dr. Lyle was funded by a pre-doctoral fellowship from the American Heart Association and received several awards, including a Merit Award for Young Investigators from the Atherosclerosis, Thrombosis and Vascular Biology council. Dr. Lyle completed her post-doctoral training in the lab of W. Robert Taylor, MD, PhD at Emory University, where she was funded by a post-doctoral fellowship from the American Heart Association. Dr. Lyle is a NIH Pathway to Independence (PARENT K99/R00) Grant Recipient and recently transitioned to an Assistant Professor position.

Dr. Lyle’s research is focused on how vascular inflammation functions to regulate new vessel formation (neovascularization) and the pathogenesis of vascular disease. Dr. Lyle has a strong interest in how inflammation influences cell proliferation and migration, both of which are required for neovascularization. She is also interested in how reactive oxygen species regulate inflammatory cytokine expression and function. Her lab uses molecular and cellular techniques to investigate how inflammation affects proliferation and migration in vitro and utilizes knockout and transgenic mouse models to investigate the in vivo processes that mediate collateral formation, a complex physiologic response that involves multiple cell types and mechanisms in concert. Ongoing research is focused on how human osteopontin isoforms (a, b, and c) function to differentially regulate neovascularization by influencing cell migration and neovascularization and how to apply this knowledge to develop future translational therapeutics to treat vascular diseases, such as peripheral artery disease.

Dr. Lyle is a member of the American Heart Association (AHA), currently serves on the Atherosclerosis, Thrombosis and Vascular Biology (ATVB) Early Career Council and is affiliated with both the ATVB and Peripheral Vascular Disease (PVD) councils. Dr. Lyle was awarded the Robert W. Hobson, II, MD Early Career Investigator Award by the AHA PVD Council in 2016. She also serves on the Emory Department of Medicine Research Steering Committee and the Emory Project M-PACT (Medicine Partnering Across the Community) Committee. Dr. Lyle directs the course “Principles and Practice of Molecular Biology in Medicine: a course for Clinical and Postdoctoral Research Fellows”.   

Publications