Publications

See full list of publications on PubMed and Google Scholar.

     

Under Review:

1. Ghosn EE, Kosuge H, Larson T, Herzenberg LA, Gambhir SS, McConnell MV, Smith BR. Carbon nanotubes for selective photoacoustic imaging of atherosclerotic macrophages.

2. Orlova D, Meehan S, Moore W, Parks D, Meehan C, Dill D, Zimmerman N, Ghosn EE, Herzenberg LA, Walther G. Science not art:  statistically sound methods for defining subsets in large multi-dimensional datasets.

3. Orlova D, Meehan S, Parks D, Moore W, Meehan C, Ghosn EE, Herzenberg LA, Walther G. QFMatch: multidimensional flow and mass cytometry samples alignment.

 

Published:

1. Min J, Raju P, Hulse K, Stevens W, Huang J, Van Roey G, Norton J, Suh L, Carter R, Price C, Weibman A, Rashan A, Ghosn EE, Homma T, Conley D, Welch K, Shintani-Smith S, Peters A, Grammer III L, Harris K, Kato A, Hwang P, Kern R, Herzenberg L, Schleimer R, Nayak J, Tan B. Evidence for altered levels of IgD in the nasal airway mucosa of patients with chronic rhinosinusitis. JACI in press 2017

2. Ghosn EE*, Waters, J, Phillips M, Yamamoto R, Long B, Yang Y, Gerstein R, Stoddart C, Nakauchi H, Herzenberg, LA. Fetal hematopoietic stem cell transplantation fails to fully regenerate the B-lymphocyte compartment. Stem Cell Reports 2016 *Corresponding Author | Recommended in F1000 prime

3. Orlova D, Zimmerman N, Meehan S, Meehan C, Waters J, Ghosn EE, Filatenkov A, Kolyagin G, Gernez Y, Moss R, Herzenberg LA, Walther G. Earth Mover's Distance (EMD): a true metric for comparing biomarker expression levels in cell populations.PLoS One 2016

4. Rothstein TL, Herzenberg LA, Holodick NE, Ghosn E. B-1 Cell Development and Function. Ann NY Acad Sci. 2015

5. Ghosn EE* & Yang Yang. Hematopoietic stem cell-independent B-1a lineage.Ann NY Acad Sci. 2015Corresponding Author

*Corresponding Author

6. Rashan A, Ghosn EE, Peterson A, Yang Y, Phillips M, Sahaf B, Herzenberg LA, Nayak JV. Characterization of immunoglobulin E plasma cells that are elevated in the upper airway mucosa of nonatopic patients with chronic rhinosinusitis without nasal polyps. Int Forum Allergy Rhinol. 2016

7. Kurnellas MP, Ghosn EE, Schartner JM, Baker J, Rothbard J, Negrin R, Herzenberg LA, Fathman CG, Steinman L, Rothbard JB. Amyloid Fibrils Activate B-1a Lymphocytes to Ameliorate Inflammatory Brain Disease. PNAS.  2015

8. Yang Y, Wang C, Yang Q, Kantor AB, Chu H, Ghosn EE, Qin G, Mazmanian SK, Han J, Herzenberg LA. Distinct mechanisms define murine B cell lineage immunoglobulin heavy chain (IgH) repertoires. eLife 2015

9. Smith B, Ghosn EE, Rallapalli H, Prescher J, Herzenberg LA, Gambhir SS. Selective uptake of single-walled carbon nanotubes by circulating monocytes for enhanced tumour delivery. Nature Nanotech. 2014 

10. Meehan S, Walther G, Moore W, Orlova D, Meehan C, Parks D, Ghosn EE, Philips M, Mitsunaga E, Waters J, Kantor A, Okamura R, Owumi S, Yang Y, Herzenberg LA and Herzenberg LA. AutoGate: automating analysis of flow cytometry data. Immunol Res. 2014

11. Araujo T, Okada S, Ghosn EE, Taniwaki NN, Rodrigues MR, Almeida SR, Mortara RA, Russo M, Campa A, Albuquerque RC. Intracellular localization of myeloperoxidase in murine peritoneal B-lymphocytes and macrophages. Cell Immunol. 2013

12. Grant J, Ghosn EE, Axtell RC, Herges K, Kuipers HF, Woodling NS, Andreasson K, Herzenberg LA, Herzenberg LA, Steinman L. Reversal of Paralysis and Reduced Inflammation from Peripheral Administration of β-Amyloid in TH1 and TH17 Versions of Experimental Autoimmune Encephalomyelitis. Sci Transl Med. 2012

*Selected for the magazine cover

13. Ghosn EE*, Yamamoto R, Hamanaka S, Yang Y, Herzenberg LA, Nakauchi H, Herzenberg LA. Distinct B-cell lineage commitment distinguishes adult bone marrow hematopoietic stem cells. PNAS. 2012

      *Corresponding Author | Highlighted in In This Issue of PNAS

14. Kusy S, Ghosn EE, Herzenberg LA, Contag CH. Development of B cells and erythrocytes is specifically impaired by the drug celastrol in mice. PLoS One 2012

15. Yang Y, Ghosn EE, Cole LE, Obukhanych TV, Sadate-Ngatchou P, Vogel SN, Herzenberg LA, Herzenberg LA. Antigen-specific memory in B-1a and its relationship to natural immunity. PNAS. 2012

16. Yang Y, Ghosn EE, Cole LE, Obukhanych TV, Sadate-Ngatchou P, Vogel SN, Herzenberg LA, Herzenberg LA. Antigen-specific antibody responses in B-1 and their relationship to natural immunity. PNAS. 2012

17. Cassado A, de Albuquerque J, Sardinha L, Buzzo CL, Faustino L, Nascimento R, Ghosn EE, Lima MR, Alvarez JM, Bortoluci KR. Cellular renewal and improvement of local cell effector activity in peritoneal cavity in response to infectious stimuli. PLoS One 2011

18. Ghosn EE*, Sadate-Ngatchou P, Yang Y, Herzenberg LA, Herzenberg LA. Distinct progenitors for B-1 and B-2 cells are present in adult mouse spleen. PNAS. 2011

      *Corresponding Author

19. Gernez Y, Tirouvanziam R, Yu G, Ghosn EE, Reshawmala N, Nguyen T, Tsai M, Galli SJ, Herzenberg LA, Nadeau KC. Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy. Int Arch Allergy Immunol. 2011

20. Ghosn EE*, Cassado A, Govoni G, Fukuhara T, Yang Y, Monack D, Bortoluci K, Almeida SR, Herzenberg LA. Two physically, functionally and developmentally distinct peritoneal macrophage subsets. PNAS. 2010

      *Corresponding Author

21. Sousa MG, Ghosn EE, Nascimento RC, Bomfim GF, Noal V, Santiago K, Silva Azevedo CM, Marques SG, Gonçalves AG, Lima Santos DW, Criado PR, Costa Martins JE, Almeida SR. Monocyte-derived dendritic cells from patients with severe forms of chromoblastomycosis induce CD4+ T cell activation in vitro. Clin Exp Immunol. 2009\

22. Ghosn EE, Yang Y, Tung J, Herzenberg LA. CD11b expression distinguishes sequential stages of peritoneal B-1 development. PNAS. 2008

23. Sousa MG, Azevedo C, Nascimento R, Ghosn EE, Santiago KL, Noal V, Bomfim GF, Marques SG, Gonçalves AG, Wagner de Castro D, Almeida SR. F. pedrosoi infection induces differential modulation of co-stimulatory molecules and cytokines in monocytes from patients with severe and mild forms of chromoblastomycosis. J Leukoc Biol. 2008

24. Yang Y, Tung J, Ghosn EE, Herzenberg LA. Division and differentiation of natural antibody-producing cells in mouse spleen. PNAS. 2007

25. Sousa MG, Ghosn EE, Almeida SR. Absence of CD4+ T cells impairs host defense of mice infected with Fonsecaea pedrosoi. Scand J Immunol. 2006

26. Hayakawa M, Ghosn EE, Sousa MG, Ferreira KS, Almeida SR. Phagocytosis, production of nitric oxide and pro-inflammatory cytokines by macrophages in the presence of dematiaceous fungi that cause chromoblastomycosis. Scand J Immunol. 2006

27. Ghosn EE, Russo M, Almeida SR. Nitric oxide-dependent killing of Cryptococcus neoformans by B-1 derived mononuclear phagocyte. J Leukoc Biol. 2006

 

     

Ghosn Lab

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We are located in Emory University's new Health Sciences Research Building (HSRB - 1760 Haygood Drive NE, Atlanta, GA 30322), 2nd floor, Room E240. Our laboratory is located in HSRB, Room E269. If you have any questions, please contact Dr. Ghosn at eghosn@emory.edu or (404) 712-3211.