Chungwen Wei, PhD
Assistant Professor of Medicine
Emory University School of Medicine
Dr. Wei earned his PhD in Biochemistry and received further training in Immunology from the University of Rochester. During his post-doctoral training, he created a line of transgenic mice that express human prostate specific antigen (PSA) in a spatial and temporal pattern that mimics humans', for which he received a US patent. These transgenic mice have been used as a model to study tumor immunotherapy by breaking tolerance to self-antigen. One of his regrets in life is that he does not have a picture of the founder mouse, although any C57BL/6 mouse can pass for it.
His current research is focused on the human B cell development and homeostasis, and the disregulation of these events in the pathogenesis of autoimmune diseases such as lupus. Among the first few labs, he identified a subset of human memory B cells devoid of the conventional CD27memory marker, which is greatly expanded in lupus patients. The link between this subset of memory Bcells and lupus disease is currently under investigation through the characterization of autoreactive B cells and gene profiling analysis. He also pursues a systems biology approach that integrates B cell profiling and clinical parameters to better understand the lupus disease.