What's Up Research Newsletter
The Emory Department of Medicine Office of Research distributes a weekly "What's Up" research newsletter filled with useful information to help faculty members, postdoctoral fellows and other researchers in the department stay informed of helpful funding opportunities, events and announcements.
Renita Wiley (Department of Medicine RAS)
Renita is the new Pre-award Lead in our Department of Medicine’s Research Administration Service (RAS) Unit. She has 20 years of research administration experience. Renita comes to the Department of Medicine’s RAS from the Yerkes RAS and before that, she worked in the Office of Sponsored Programs. She has also worked in research administration at UNC-Chapel Hill and Duke University. In her free time she loves to watch UNC basketball and Carolina Panthers & San Francisco 49ers football.
If you have questions about content in prior research newsletters please review the archived newsletters below‚ If you do not find the information you are looking for please contact Emalee Haines at DOMResearch@emory.edu.
March 21, 2017
March 14, 2017
March 7, 2017
February 28, 2017
February 21, 2017
February 14, 2017
February 7, 2017
January 31, 2017
January 24, 2017
January 18, 2017
January 10, 2017
January 4, 2017
December 21, 2016
December 13, 2016
December 7, 2016
November 29, 2016
November 22, 2016
November 15, 2016
November 9, 2016
October 11, 2016
October 4, 2016
Jinhu Wang, Ph.D. (Cardiology)
Dr. Wang is an assistant professor in the Division of Cardiology. He received his PhD in Developmental Biology at the Chinese Academy of Science and completed his postdoctoral research training with Dr. Kenneth Poss at Duke University. His broad research goal is to understand how regenerative responses to injury have been optimized in non-mammalian vertebrates like zebrafish in order to identify potential targets that are responsible for regenerative deficiencies in mammals. The coronary vasculature supplies oxygen and nutrients to a large region of myocardium, and re-vascularization is considered an important step for heart recovery. Adult zebrafish have a dense coronary vasculature, and regenerated myofibers become re-vascularized in a few weeks. Using this model, Dr. Wang investigates the molecular mechanisms of coronary re-vascularization during heart regeneration by utilizing genetic manipulation and live imaging techniques. His results will provide insights into the cardiac repair process in mammals. In his free time, he enjoys traveling, hiking, tennis, fishing and swimming.
Kiyoko Takemiya, MD, PhD (Cardiology)
Dr. Takemiya joined Emory from Kurume University in Japan. She recently received an American Heart Association Scientist Development grant to support her research on the detection of bacterial infections associated with medical devices. Currently, the diagnosis of device infection is made based on symptoms or clinical signs, and when it is diagnosed, the infection has already expanded and damaged the surrounding tissue. Dr. Takemiya’s work aims to detect infection in the very early stages with no clinical signs or symptoms, which will help to improve the prognosis of patients and to reduce unnecessary surgeries.
To detect small amount of bacteria, Dr. Takemiya’s team focused on the differences in sugar metabolism between bacteria and mammalian cells. Maltodextrin, a kind of sugar, is used by bacteria as a major energy source through the “maltodextrin transporter,” but cannot be internalized by mammalian cells. The maltodextrin transporter is large enough to pass an imaging probe conjugated with maltodextrin or its analogue, leading to accumulation in bacteria, and allowing sensitive and specific detection of bacteria. Dr. Takemiya uses rat models to test these maltodextrin and maltodextrin analogue-based imaging probes for near infrared imaging and positron emission tomography (PET) imaging to detect the existence of bacteria. In her free time, Dr. Takemiya enjoys cooking, reading, playing with jigsaw puzzles, and crafting.
Qian “Elsie” Xu (Cardiology)
Qian (Elsie) Xu is a visiting Chinese medical student who came to Emory to conduct biomedical research as part of Emory’s partnership with Xiangya School of Medicine, one of China’s leading medical programs. She decided to work in Dr. Kathy Griendling‘s research group because they investigate the role of reactive oxygen species in smooth muscle function and the role of oxidative stress in the pathogenesis of vascular disease. Elsie is studying the redox-regulation of actin cytoskeleton in vascular smooth muscle cell attachment while also exploring the underlying redox signaling pathway during cell adhesion. After completing her research project at Emory, Elsie will return to China to complete her MD. In her free time, she enjoys traveling, her favorite activity; she also enjoys cooking, watching movies, and playing the ukulele.
Brandi Wynne, PhD (Renal Medicine)
Dr. Brandi M. Wynne is an instructor of medicine in the Division of Renal Medicine with a background in cardio-renal physiology and pharmacology. Previously, Dr. Wynne was a postdoctoral fellow under Dr. Robert Hoover, where she focused on the hormonal regulation of the sodium chloride cotransporter (NCC) and the epithelial sodium channel. Her current research investigates the role of inflammation in the etiology of salt-sensitive hypertension. Hypertensive patients frequently have a normal level of aldosterone, the main ligand for the mineralocorticoid receptor (MR), which regulates sodium transport proteins in the distal nephron. However, these patients often have indices of aldosterone excess and respond positively to MR antagonists, suggesting that there are alternative mechanisms of MR activation. Dr. Wynne’s research has shown that interleukin-6 (IL-6) plays a role in this process. She recently discovered that IL-6 transactivates the MR, leading to activation of the NCC. Understanding how renal-specific immune cells and cytokines regulate sodium homeostasis is the focus of her NIH NIDDK K01 application. In her spare time, Dr. Wynne enjoys the arts, politics, and traveling as much as possible.
Yang Xie (Renal Medicine)
Yang Xie is a visiting medical student in her 8th year from Xiangya School of Medicine, Changsha, China; her school is the second oldest medical school in China. She is conducting research in the Renal Division under the guidance of Dr. Russ Price. Her interest in nephrology and the consequences of chronic kidney disease (CKD) began during her 5th year of clinical medicine. Muscle atrophy is a common problem in CKD patients and diabetic patients who frequently develop nephropathy. While at Emory, Yang is investigating a new signaling pathway that contributes to the expression of myostatin, a myokine that contributes to skeletal muscle loss by altering insulin signaling and increasing the expression of proteins that disrupt muscle proteostasis. Outside of the lab, she enjoys traveling, cooking, and painting.
Melissa Stevens, MD (Hospital Medicine)
Dr. Stevens won the 2016 Top Overall Research Prize for her abstract and oral presentation, entitled “EQUiPPED Expansion: Results from a multi-site quality improvement initiative to change prescribing practices in VA Medical Center Emergency Departments (EDs).” Out of 141 abstracts submitted to the 9th annual Department of Medicine Research Day, Dr. Stevens’ abstract and oral presentation scores ranked the highest. As the prize recipient, she will receive $1,000 to be used toward research costs. Read more about the EQUiPPED project on the Department of Medicine’s blog, Emory Daily Pulse.
Clintoria Williams, PhD (Renal Medicine)
Learn more about Dr. Williams’ work at the 9th annual Department of Medicine Research Day on Friday, 10/28 in the Cox Hall Ballroom, where she will present "NADPH oxidase-2 mediates zinc deficiency-induced oxidative stress and kidney damage."
Madeleine Hackney, PhD (General Medicine and Geriatrics)
Dr. Hackney’s DREAMS (Developing a Research Participation Enhancement and Advocacy Training Program for Diverse Seniors) project grew out of an ongoing problem in clinical research. Older adults with low socioeconomic status and/or from racial or ethnic minority populations are historically underrepresented in research because of multiple barriers, including distrust of the research community, difficulties with access, ageism, health literacy challenges, and strict trial inclusion criteria. To help break down the existing barriers and build relationships with these underrepresented populations, Dr. Hackney decided to use the tango to treat mobility problems in people with Parkinson’s disease. While some of the participants danced, those assigned to the control group attended educational sessions on various health issues. The interactive educational sessions were so popular, both with learners and the teachers, that Dr. Hackney suspected they could serve to bring together a group of diverse seniors for the DREAMS project. Funding from the Patient Centered Outcomes Research Institute (PCORI) gave her the chance to empirically demonstrate her theory. Read more on the Department of Medicine's blog, Emory Daily Pulse, and in a recent feature inAtlanta Magazine. (Photo credit: Kaylinn Gilstrap, Atlanta Magazine.)
Dr. Hoover is an associate professor of medicine in the Division of Renal Medicine who studies the regulation of thiazide-sensitive sodium chloride (rNCC) cotransporters in various models of hypertension. His lab currently examines the intracellular mechanisms by which aldosterone and angiotensin regulate rNCC with the goal of increasing our understanding of the mechanisms that cause hypertension. This knowledge will hopefully lead to improved treatment and quality of life for patients affected by kidney disorders. Read more…
In The News
2017 Doctors’ Day nominees – Division of Cardiology
2017 Doctors’ Day nominees – Pulmonary, Allergy, Critical Care and Sleep Medicine
Match Day at Emory reveals residency destinations for Class of 2017 medical students
2017 Emory Doctors’ Day nominees – General Medicine and Geriatrics