Klein Research Focus Areas
The polyuria that occurs in diabetic patients is generally ascribed to an osmotic diuresis. We believe that the mechanisms are more complex. The production of concentrated urine requires complex interactions among the medullary nephron segments and vasculature. Recent reports from the CDC indicate that diabetes mellitus has reached epidemic proportions in the U.S. The polyuria that occurs in diabetic patients is generally ascribed to an osmotic diuresis. We believe that the mechanisms are more complex. Several metabolic and hormonal abnormalities present in diabetes mellitus and could contribute to abnormalities in solute and water handling. A major emphasis of my research is to identify the cellular and molecular mechanisms that contribute to changes in water and solute homeostasis that occur in uncontrolled diabetes.
Our recent findings were the first to propose that compensatory changes in renal medullary transport proteins occurred during uncontrolled diabetes. In addition to working with transport processes in diabetes mellitus, we are also interested in nephrogenic diabetes insipidus (NDI). This is a water handling pathology that involves a severe polyuria and is a major lifestyle determinant. NDI can be genetic or acquired. Acquired NDI frequently results from drug therapies such as treatment with Lithium for dipolar disorders. Understanding the transport processes responsible for urine concentration allows us to suggest ways to compensate for, or perhaps even prevent, the concentrating defect involved in NDI. We are therefore investigating the regulation of urea and water transporters to determine if or how they are involved in NDI.
Please find a full list of Dr. Klein's publications on NCBI.