Xiaonan Wang, MD, MS

Associate Professor of Medicine

Department of Medicine

Office: WMB 338C

Phone: 404-727-1798

Fax: 404-727-3425

Email: xwang03@emory.edu

Biography

Dr. Xiaonan Wang received her MS in biochemistry from Peking Union Medical College, China and her MD from China Medical University. After receiving her MD, she accepted a position as an attending physician at the PUMC Hospital in China. In 1997, Dr. Wang joined the Division of Renal Medicine at Emory University as an instructor, and in May of 2001, she was named an assistant professor of medicine.

The objective of Dr. Wang's research is to identify molecular and biochemical mechanisms that lead to protein malnutrition in catabolic diseases related to insulin resistance, such as chronic renal disease and diabetes. She uses transgenic mice and cell culture systems to test her hypotheses. Currently, she is exploring the use of gene therapy (using lentiviruses to deliver target genes) to treat muscle protein loss in insulin-deficient diabetic animals.

Publications

Xiaonan Wang, Chinsky JM and Price SR. Acidification and glucocorticoid independently regulate branched-chain Amino acid dehydrogenase subunit genes. Am J Physiol (Cell Physiol). 2001;280:C1176-83.

Xiaonan Wangand Price SR. Activation of branched-chain a-ketoacid dehydrogenase (BCKAD) in LLC-PK1-GR101 cells: Glucocorticoids and acidification suppress BCKAD kinase expression by different Mechanisms. Am J Physiol (Renal Physiol). 2004;286:F504-8.

Du J, Wang Xiaonan Christiane Miereles, James L. Bailey, Bin Zheng, Price SR and Mitch WE. Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions. J Clin Invest. 113:115-23, 2004.

Xiaonan Wang, Hu, JP, Hu ZY, Du J, and Mitch WE. Insulin resistance accelerates muscle protein degradation: activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling. Endocrinology: 147:4160-8, 2006

Xiaonan Wang, Hu, JP, Jie Du and Klein JD. X-chromosome linked inhibitor of apoptosis protein (XIAP) inhibits muscle proteolysis in insulin deficient mice. Gene Therapy, 14:711-20, 2007

Xiaonan Wang, Hu, JP, Price SR. Inhibition of PI3-kinase signaling by glucocorticoids results in increased branched-chain amino acid degradation in renal epithelial cells, Am J Physiol (Cell Physiol), 292:C1874-9, 2007

Hu ZY, Lee IH, Xiaonan Wang, Zhang LP, Sheng HM, Du J, and Mitch WE. PTEN expression contributes to the regulation of muscle protein degradation in diabetes, Diabetes, 56(10):2449-56, 2007

Zhou QG, Du J, Hu ZY, Walsh K and Xiaonan Wang. Evidence for Adipose-Muscle Crosstalk: Opposing Regulation of Muscle Proteolysis by Adiponectin and Fatty Acids, Endocrinology 148(12) 5696-5705, 2007

Hu, JP, Klein JD, Jie Du and Xiaonan Wang. Cardiac Muscle Protein Catabolism in Diabetes Mellitus: Activation of the Ubiquitin-Proteasome System by Insulin Deficiency. Endocrinology, 149 (11)5384-90, 2008

Xiaonan Wang, Jie Du, Janet D. Klein, James L. Bailey and William E. Mitch. Chronic Kidney Disease Changes Exercise-induced Protein Metabolism and Muscle Progenitor Cell Function Kidney International, 76:751-759, 2009

Liping Zhang, Jie Du, Xiaonan Wang and William E. Mitch. Chemokine CXCL16 Regulates Neutrophil and Macrophage Infiltration into Injured Muscle Promoting Muscle Regeneration, Am J Path, 5:2519-2527, 2009

Liping Zhang, Xiaonan Wang, Jie Du, and William E. Mitch. Satellite Cell Dysfunction and Impaired IGF-1 Signaling Cause CKD-Induced Muscle Atrophy, J Am Soc Nephrol, 21:419-27, 2010

Zhaoyong Hu, Huiling Wang, In Hee Lee, Swati Modi, Xiaonan Wang, Jie Du and William E. Mitch; PTEN inhibition improves muscle regeneration in mice fed a high fat diet. Diabetes, 59:1312-20, 2010

Junping Hu, Jie Du, Liping Zhang, S. Russ Price, Janet D. Klein and Xiaonan Wang. XIAP Reduced Muscle Proteolysis Induced by CKD. J Am Soc Nephrol, 21:1174-83, 2010.

Xiaonan Wang, Liping Zhang, William E. Mitch, Joseph M. LeDoux, Junping Hu and Jie Du. Caspase-3 Cleaves Specific 19S Proteasome Subunits in Skeletal Muscle Stimulating Proteasome Activity. JBC 285:21249-57, 2010.

Liping Zhang, Vik Rajan, Eugene Lin, Zhaoyong Hu, H.Q. Han, Xiaolan Zhou, Yanping Song,

Hosung Min, Xiaonan Wang, Jie Du1, and William E. Mitch. Pharmacological Inhibition of Myostatin Suppresses Systemic Inflammation and Muscle Atrophy in Mice with Chronic Kidney Disease. Accepted, FASEB Journal, 2011