William Charles O'Neill, MD
Professor of Medicine
Department of Medicine
Office: WMRB 338
BiographyDr. O'Neill has an active basic and translational research program and is also director of the ultrasonography program in the Renal Division. His NIH-sponsored research is in the area of vascular calcification, specifically on the role of endogenous pyrophosphate in the etiology of vascular calcification. Dr. O'Neill's clinical interest is in renal imaging and interventional nephrology. He directs the ultrasound program in the Renal Division, which he initiated in 1994, and directs numerous courses for nephrologists at Emory and at national and international meetings. He is past-president and founding member of the American Society of Diagnostic and Interventional Nephrology.
Current research focuses on the pathophysiology of vascular calcification in renal failure with particular emphasis on the role of endogenous calcification inhibitors such as pyrophosphate and matrix Gla protein. In addition, the role of vitamin D in vascular calcification is being investigated. Potential therapies based on the central role of pyrophosphate are being developed and tested, including pyrophosphate analogs and novel inhibitors of alkaline phosphatase. Studies are performed on animal models and on an in vitro vessel culture system developed in this laboratory.
Dr. O'Neill directs the ultrasonography service in the renal division. The service performs diagnostic studies of kidneys, renal transplants, and urinary bladders, as well as guidance for percutaneous renal biopsies. This program has been in operation since 1994 and currently over 1200 studies are performed per year. Dr. O'Neill has directed CME courses for outside nephrologists since 1997. Information on these courses can be found on the education page of the Renal Division. This clinical area has also been the focus of research relating to imaging in renal disease.
Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification. Sheen, C.R., Kuss, P., Narisawa, S., Yadav, M.C., Nigro, J., Wang, W., Chhea, T.N., Sergienko, E.A.,Kapoor, K., Jackson, M.R., Hoylaerts, M.F., Pinkerton, A.B., O’Neill, W.C., and Millán, J.L. J Bone and Mineral Research, in press.
Tantisattamo, E., Han, K.H., and O’Neill, W.C. Increased vascular calcification in patients receiving warfarin. Arteriosclerosis, Thrombosis, and Vascular Biology 35:237-242, 2015.
Han, K.H., Schneider, T.M., Hennigar, R.A., and O’Neill, W.C. Prevalence of non-atheromatous lesions in peripheral arterial disease. Arteriosclerosis, Thrombosis, and Vascular Biology 35:237-242, 2015.
Abou-Hassan, N., Tantisattamo, E., D’Orsi, E., O’Neill, W.C. Clinical significance of medial arterial calcification in end-stage renal disease. Kidney International 87:195-199, 2015.
Lomashvili, K.A., Narisawa, S., Millán, J.L., and O’Neill, W.C. Vascular calcification is dependent on plasma levels of pyrophosphate. Kidney International 85:1351-1356, 2014.
Rathan, S., Yoganathan, A.P., and O’Neill, W.C. The role of inorganic pyrophosphate in aortic valve calcification. Journal of Heart Valve Disease 23:387-394, 2014.
Lomashvili, K.A., Wang, X., and O’Neill, W.C. The role of local versus systemic vitamin D receptors in vascular calcification. Arteriosclerosis, Thrombosis, and Vascular Biology 34:146-151, 2014.
O’Neill, W.C. and Adams, A.L. Breast arterial calcification in chronic kidney disease: absence of smooth muscle apoptosis and osteogenic transdifferentiation. Kidney International 85:668-676, 2014.
O’Neill, W.C. Sodium thiosulfate: mythical treatment for a mysterious disease? Clin J Am Soc Nephrol. 8:1068-1069, 2013.
Abou-Hassan, N., D’Orsi, E.T., D’Orsi, C.J., and O’Neill, W.C. The risk for medial arterial calcification in chronic kidney disease. Clin J Am Soc Nephrol. 7:275-279, 2012.
O’Neill, W.C. and Hardcastle, K.I. The chemistry of thiosulfate and vascular calcification. Nephrology, Dialysis, and Transplantation 27:521-526, 2012.
Lomashvili, K. A., Wang, X., Wallin, R., and O’Neill, W.C. Matrix Gla protein metabolism in vascular smooth muscle and role in uremic vascular calcification. J Biol Chem 286:28715-28722, 2011.
Villa Belosta, R., Wang, X., Millan, J.L., Dubyak, G.R., and O’Neill, W.C. Extracellular pyrophosphate metabolism and calcification in vascular smooth muscle. Am J Physiol Heart and Circulatory 301:H61-H68, 2011.
O’Neill, W.C., Lomashvili, K.A., Faugere, M.-C., Malluche, H.H., and Riser, B.L. Treatment with pyrophosphate inhibits uremic vascular calcification. Kidney International 79:512-517, 2011.
Sutliff, R.A., Walp, E.R., Elkhatib, S., Lomashvili, K.A., and O’Neill, W.C. Effect of medial vascular calcification on arterial function in experimental uremia. Am J Physiol Renal Physiology 301:F78-F83, 2011.
Duhn, V., D’Orsi, E.T., Johnson, S., D’Orsi, C.J., and O’Neill, W.C. Breast arterial calcification: a marker of medial vascular calcification in chronic kidney disease. Clin J Am Soc Nephrol. 6:377-382, 2011.
Lomashvili, K.A., Monier-Faugere, M.-C., Wang, X., Malluche, H.H., and O’Neill, W.C. Effect of bisphosphonates on vascular calcification and bone metabolism in experimental renal failure. Kidney International 75:617-625, 2009.
Prosdocimo, D.A., Douglas, D.C., Romani, A.M., O’Neill, W.C., and Dubyak, G.R. Autocrine ATP release coupled to extracellular pyrophosphate accumulation in vascular smooth muscle cells. Am. J. Physiol 296:C828-C839, 2009.
Recent clinical publications
O’Neill, W.C. Renal resistive index: a case of mistaken identity. Hypertension, in press.
O’Neill, W.C. Renal Relevant Radiology: Use of Ultrasound in Kidney Disease and Nephrology Procedures. Clin J Am Soc Nephrol, 2014, in press.
O’Neill, W.C. Structure, not just function. Kidney International 85: 503-505, 2014.
Bardelli, M., Yezvlin, A., and O’Neill, W.C. Imaging For Renovascular Disease. Seminars in Nephrology 31:272-282, 2011.
Rahbari-Askoui, F., Taylor, A.T., O’Neill, W.C.: “Ultrasonography and Nuclear Medicine” in Diseases of the Kidney & Urinary Tract, Ninth Edition. R.W. Schrier, Ed., 2011.
O’Neill, W. C. A Daunting Task but Largely Successful in Developing Meaningful CKD-MBD Guidelines. Seminars in Dialysis 24:25-27, 2011.
Johnson, S., Rishi, R., Andone, A., Khawandi, W., Yuan, Y., Al-Said, J.M., Gletsu, N., Lin, E., Baumgarten, D.A. , and O’Neill, W.C. Determinants and functional significance of renal parenchymal volume in adults. Clin J Am Soc Nephrol. 6:70-76, 2011.
O’Neill, W.C., Wasse, M., Ash, S.R., Asif, A: “Interventional Nephrology” in Comprehensive Clinical Nephrology, J. Feehally, J. Floege, and R. J. Johnson, Eds., 2010. Elsevier.
Gosmanova, E.O., Wu S., and O'Neill, W.C. Application of ultrasound in nephrology practice. Adv. in Chronic Kidney Dis 16:396-404, 2009.
Gosmanova, E.O., Baumgarten, D.A., and O'Neill, W.C. Acute kidney injury in a patient with unilateral ureteral obstruction. Am J of Kidney Dis 54:775-9, 2009.
Berns, J. and O’Neill, W.C. Performance of procedures by nephrologists and nephrology fellows at US nephrology training programs. Clinical J of the Am Soc Nephrol 3:941-947, 2008.
O’Neill, W.C. B-mode sonography in acute renal failure. Nephron Clinical Practice 103:c19-c23, 2006.
O’Neill, W.C., Robbin, M.L., Bae, K.T., Grantham, J.J., Chapman, A.B., Guay-Woodford, L., Torres, V.E., King, B.F., Wetzel, L.H., Thompson, P.A., and Miller, J.P. Sonographic Assessment of the Severity and Progression of Autosomal-Dominant Polycystic Kidney Disease: the Consortium of Renal Imaging Studies in Polycystic Kidney Disease (CRISP). Am. J. Kidney Dis. 46:1058-1064, 2005.
Moghazi, S., Jones, E., Schroepple, J., Arya, K., McClellan, W. and O’Neill, W.C. Correlation between renal histopathology and sonographic findings. Kidney International 67:1515-1520, 2005.
Al-Said, J., Moghazi, S., Brumback, M., Baumgarten, D. A., and O’Neill, W.C. Reduced renal function in patients with simple renal cysts. Kidney International 65: 2303-2308, 2004.
Al-Said, J.M. and O’Neill, W.C. Reduced kidney size in patients with simple renal cysts. Kidney International 64: 1059-1064, 2003.
Chapman, A., Guay-Woodford, L., Grantham, J., Torres, V., Bae, K., Baumgarten, D., Kenney, P., King, B.F., Glockner, J., Wetzel, L.H., Brummer, M., O’Neill, W.C., Robbin, M., Bennett, W., Klahr, S., Hirschman, G., Kimmel, P., Thompson, P., Miller, J. Renal structure in early autosomal dominant polycystic kidney disease (ADPKD): the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohort. Kidney International 64: 1059-1064, 2003.
O’Neill, W.C. and Baumgarten, D.A. Ultrasonography in renal transplantation. Amer. J. Kidney Diseases 39:663-678, 2002.
O’Neill, W.C. Sonography of the kidneys and urinary tract. Sem. Nephrol. 22:242-253, 2002.
Manley, J. and O’Neill, W.C. How echogenic is echogenic? Quantitative acoustics of the renal cortex. Amer. J. Kidney Diseases 37:706-711, 2001.
O’Neill,W.C. Sonographic evaluation of renal failure. Amer. J. Kidney Diseases 35:1021-1038, 2000.