Robert Hoover Jr., MD

Associate Professor of Medicine

Department of Medicine

Biography

Robert S. Hoover received a Bachelor of Arts degree in Chemistry from Howard University in 1987 and his medical degree from the University of California Los Angeles (UCLA) in 1991. He was an intern and resident in internal medicine at Emory University in 1994 and a fellow in nephrology at Brigham and Women’s Hospital as well as Vanderbilt University from 1995-1998. He then served on faculty at Vanderbilt, Yale and the University of Chicago.

He is currently Associate Professor of Medicine at Emory University, Department of Medicine, Renal Division. Dr. Hoover’s research focuses on regulation of the thiazide-sensitive Na-CI cotransporter (NCC). They are presently focused on examining the intracellular mechanisms that mediate hormonal regulation of the cotransporter by aldosterone and angiotensin.

Dr. Hoover is a Fellow of the American Society of Nephrology, a Councilor of the Southern American Federation of Medical Research, a Faculty Member of the Renal function & transport physiology section in the “Faculty of 1000 Medicine Project” and an active member of the American Physiological Society.

He has received numerous honors and awards including: National Merit Scholar, National Achievement Scholar, Minority Access to Research Careers (MARC) Fellowship, Phi Beta Kappa, Goldwyn Fellowship, Amos Medical Faculty Development Program Scholar, Bowman Society Invited Lecturer, and American Federation for Medical Research Centocor Scholar Award

Dr. Hoover’s research focuses on regulation of the thiazide-sensitive Na-CI cotransporter (NCC). This is the major effector of salt handling in the mammalian Distal Convoluted Tubule. Hyperactivity of this cotransporter results in hypertension and reduced activity results in hypotension. His lab utilizes techniques such as cell culture, confocal microscopy, immunoblotting, PCR, xenopus oocyte expression system, site-directed mutagenesis and transgenic animal studies to examine the regulation of the cotransporter. The Hoover lab recently described the first instance of regulated endocytosis of NCC. They are presently focused on examining the intracellular mechanisms that mediate hormonal regulation of the cotransporter by aldosterone and angiotensin.