Pulmonary
 

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Research Labs


Jesse Roman, MD

The lab for Matrix Biology

 

Dr. Roman's research focuses on the role of extracellular matrices and matrix integrin receptors in lung vasculogenesis Role of extracellular matrices in lung injury and repair Control of proinflammatory gene expression by extracellular matrices Tissue remodeling in granulomatous inflammation in sarcoidosis and tuberculosis Role of nicotinic acetylcholine receptors in control of fibronectin expression


Mike Hart, MD

 

 
  • Determining the mechanisms by which reactive oxygen and nitrogen species alter endothelial barrier function.
  • Determining how fatty acids modulate endothelial nitric oxide production.
  • Examining the mechanisms by which alcohol ingestion increases the risk of ARDS.
  • Activation of peroxisome proliferator-activated receptor gamma increases endothelial nitric oxide release.

David Guidot , MD

The lab for Alcohol and Lung Biology

 

The focus of Dr. Guidot's lab is identifying mechanisms
by which oxidative stress injures the lung. Currently, a significant aspect of this work involves the study of how chronic ethanol ingestion perturbs the homeostasis of the critical antioxidant, glutathione, and how this glutathione depletion leads to an array of cellular defects that render the lung susceptible to acute edematous injury.


 
 
 

 

 

 




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