Research Publications by Emory ARC Investigators 

Moss MB, Bucher FA, Moore EE, and Parsons PE. The role of chronic alcohol abuse in the develop ment of Acute Respiratory Distress Syndrome in adults. JAMA 275:50-54, 1996.

Holguin F, Moss IM, Brown LS, and Guidot DM. Chronic ethanol ingestion impairs alveolar type II cell glutathione ho meostasis and function and predisposes to endotoxin- mediated acute edematous lung injury in rats. J Clin Invest 101:761-768, 1998.

Lois M, Brown LAS, Moss M, Roman J, and Guidot DM. Ethanol ingestion increases activation of matrix metalloproteinases in rat lungs during acute endotoxemia. Am J Respir Crit Care Med 160:1354-1360, 1999.

Guidot DM, Modelska K, Lois M, Jain L, Moss IM, Pittet JF, and Brown LAS. Ethanol ingestion via glutathione depletion impairs alveolar epithelial barrier function in rats. Am J Physiol: Lung Cell Mol Physiol 279:L127-L135, 2000.

Guidot DM, and Brown LAS. Mitochondrial glutathione replace ment restores surfactant synthesis and secretion in ethanol-fed rats. Alcoholism:Clin Exp Res 24:1070-1076, 2000.

Moss M, Guidot M, Wong-Lambertina M, Ten Hoor T, Perez RL, and Brown LAS. The effects of chronic alcohol abuse on pulmonary glutathione ho meostasis. Am J Respir Crit Care Med 161:414-419, 2000.

Brown LAS, Harris FL, and Guidot DM. Chronic ethanol ingestion potentiates TNF- mediated oxidative stress and apoptosis in rat alveolar type II cells. Am J Physiol (Lung Cell Mol Physiol) 281:L377-L386, 2001.

Brown LAS, Harris FL, Bechara R, and Guidot DM. Effect of chronic ethanol ingestion on alveolar type II cell glutathione and inflammatory mediator-induced apoptosis. Alcohol Clin Exp Res 25:1078-1085, 2001.

Guidot DM, and Roman J. Chronic ethanol ingestion increases susceptibility to acute lung injury:role of oxidative stress and tissue remodeling. Chest 122:309S-314S, 2002.

Moss M, Parsons PE, Steinberg KP, Hudson LD, Guidot DM, Burnham EL, and Cotsonis GA. Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndro me and severity of multiple organ dysfunction in patients with septic shock. Crit Care Med 31:869-877, 2003.

Burnham EL, Brown LAS, Halls L, and Moss M. Effects of chronic alcohol abuse on alveolar epithelial barrier function and glutathione ho meostasis. Alcohol Clin Exp Res 27:1167-1172, 2003.

Bechara RI, Brown LAS, Eaton DC, Roman J, and Guidot DM. Chronic ethanol ingestion increases expression of the angiotensin II type 2 (AT2) receptor and enhances tumor necrosis factor- a and angiotensin II-induced cytotoxicity via AT2 signaling in rat alveolar epithelial cells. Alcohol Clin Exp res 27:1006-1014, 2003.

Pelaez A, Bechara RI, Joshi PC, Brown LAS, and Guidot DM. Granulocyte/macrophage colony stimulating factor treat ment improves alveolar epithelial barrier function in alcoholic rat lung. Am J Physiol (Lung Cell Mol Physiol) 286: L106-L111, 2004.

Bechara RI, Brown LAS, Roman J, Joshi PC, and Guidot DM. Transforming growth factor B1 expression and activation is increased in the alcoholic rat lung. Am J Respir Crit Care Med 170:188-194, 2004.

Brown LA, Harris FL, Ping XD, Gauthier TW. Chronic ethanol ingestion and the risk of acute lung injury:a role for glutathione availability? Alcohol 33:191-7, 2004.

Gauthier TW, Manar MH, Brown LA. Is maternal alcohol use a risk factor for early-onset sepsis in premature newborns? Alcohol 33:139-45, 2004.

Bechara RI, Pelaez A, Palacio A, Joshi PC, Hart CM, Brown LA, Raynor R, Guidot DM.  Angiotensin II mediates glutathione depletion, transforming growth factor beta1 expression, and epithelial barrier dysfunction in the alcoholic rat lung. Am J Physiol (Lung Cell Mol Physiol) 289:L363-70, 2005.

Guidot DM, Hart CM. Alcohol abuse and acute lung injury:epidemiology and pathophysiology of a recently recognized association. J Investig Med 53:235-45, 2005.

Gauthier TW, Drews-Botsch C, Falek A, Coles C, Brown LA. Maternal alcohol abuse and neonatal infection. Alcohol Clin Exp Res. 29:1035-43, 2005.

Gauthier TW, Ping XD, Harris FL, Wong M, Elbahesh H, Brown LA. Fetal alcohol exposure impairs alveolar macrophage function via decreased glutathione availability. Pediatr Res. 57:76-81,2005.

Joshi PC, Applewhite L, Ritzenthaler JD, Roman J, Fernandez AL, Eaton DC, Brown LAS, Guidot DM. Chronic ethanol ingestion in rats decreases granulocyte-macrophage colony-stimulating factor receptor expression and downstream signaling in the alveolar macrophage. J Immunol 175:6837-6845, 2005.

Joshi PC., Applewhite LD, Mitchell P, Fernainy K, Roman J, Eaton DC, Guidot DM.

GM-CSF receptor expression and signaling is decreased in lungs of ethanol-fed

rats. Am J Physiol Lung Cell Mol Physiol 291:L1150-L1158, 2006.

Fernandez AL, Koval M, Fan X, Guidot DM.  Chronic alcohol ingestion alters claudin expression in the alveolar epithelium of rats.  Alcohol 41(5):371-379, 2007.

Brown LA, Ritzenthaler JD, Guidot DM, Roman J.  Alveolar type II cells from ethanol-fed rats produce a fibronectin-enriched extracellular matrix that promotes monocyte activation.  Alcohol 41(5):317-324, 2007.

Otis JS, Brown LA, Guidot DM. Oxidant-induced atrogin-1 and transforming growth factor beta1 precede alcohol-related myopathy in rats.  Muscle Nerve 36(6):842-848, 2007.

Joshi PC., Guidot DM. The alcoholic lung: epidemiology, pathophysiology, and

potential therapies. Am J Physiol Lung Cell Mol Physiol (Invited review) 292: L813-

L823, 2007.

Mitchell PO, Guidot DM.  Alcohol ingestion by donors amplifies experimental airway disease after heterotopic transplantation.  Am J Respir Crit Care Med 176(11):1161-1168, 2007.

Kleinhenz DJ, Sutliff RL, Polikandriotis JA, Walp ER, Dikalov SI, Guidot DM, Hart CM.  Chronic ethanol ingestion increases aortic endothelial nitric oxide synthase expression and nitric oxide production in the rat.  Alcohol Clin Exp Res 32(1):148-154, 2008.