Aneesh K Mehta, MD

Associate Professor of Medicine

Emory University School of Medicine

Assistant Director of Transplant Infectious Diseases and Associate Chief of Service - Infectious Diseases

Emory University Hospital

Consultant for Occupational Health and Injury

Yerkes National Primate Institute

Education

  • BS, Emory University, 1999
  • MD, University of Oklahoma, 2003
  • Internship, Emory University School of Medicine, 2004
  • Residency, Emory University School of Medicine, 2006
  • Fellowship, Emory University School of Medicine, 2006

Biography

Dr. Mehta received his M.D. from the University of Oklahoma in 2003. He completed his Internal Medicine internship and residency in the J. Willis Hurst Program at the Emory University School of Medicine. He went on to complete his fellowship in Infectious Diseases, Clinical Investigator track, also at the Emory University School of Medicine. During these training programs, he was awarded the Resident Achievement award, twice, and the J. Willis Hurst Fellow Teaching Award.

In July 2009, Dr. Mehta joined the faculty of Emory University as an Assistant Professor of Medicine in the Division of Infectious Diseases, and as the Assistant Director of the Transplant Infectious Diseases Section. In 2013, he was made Associate Chief of ID Services for Emory University Hospital, Wesley Wood Hospital, and Emory University Orthopedic and Spine Hospital

Dr. Mehta's research and clinical paths have focused on treatment of and protection against infections in immunocompromised hosts, including patients with organ transplants, limb transplants, stem cell transplants, leukemia/lymphoma, cystic fibrosis, and HIV/AIDS.

Dr. Mehta's research area is broadly within clinical and translational Transplant Infectious Diseases, with a primary research aim to develop predictive immunologic and virologic signatures of risk for viral diseases in patients receiving immunosuppressive agents. He primarily employs polychromatic flow cytometry to phenotypically and functionally describe subsets of the protective immune system.

He is currently the co-investigator and primary clinical investigator on the Protective Immunity Project (PIP), a collaborative research projected between the Emory Transplant Center (Christian Larsen, MD, DPhil), the Emory Vaccine Center (Rafi Ahmed, PhD) and the NIH. Dr. Mehta also serves as a co-investigator and clinical investigator of Project 4 (Rafi Ahmed) of the Emory University Influenza Pathogenesis & Immunology Research Center (IPIRC), is one of five national Influenza Centers of Excellence funded by NIH/NIAID. In this project, the group hopes to discern the differences in immunologic memory elicited by different influenza vaccines. Dr. Mehta also serves at the co-investigator and PI of the Viralogic Monitoring Cores of Emory's Clinical Trials in Organ Transplantation (CTOT) and Clinical Trials in Organ Transplantation in Clinical (CTOT-C) trials, including CTOT-C02, CTOT-10, CTOT-15, and CTOT-16. Recently, Dr. Mehta has replaced Dr, Allan Kirk as the PI of the Emory Transplant Center's Immune Monitoring and Assay Development in Organ Transplant Recipients (IMP) and as the Directory of Emory Transplant Biorepository.

Dr. Mehta attends on the Emory University Hospital Transplant Infectious Diseases, Emory University Hospital General Infectious Diseases, and the Emory University Orthopedic and Spine Hospital Infectious Diseases consultation services.

As Assistant Director of the Transplant Infectious Diseases, Dr. Mehta aids G. Marshall Lyon III, Director of Transplant Infectious Diseases, in developing programatic improvements in care of transplant recipients at the Emory Transplant Center and Emory University Hospital.

Dr. Mehta also serves as the Consultant for Occupational Exposure at Emory University's Yerkes National Primate Center. In this role, he supervises the care of employees at Yerkes who have incurred a work related exposure or injury, including Herpes-B exposures.

Interests

  • Dr. Mehta's research area is broadly within clinical and translational Transplant Infectious Diseases, with a primary research aim to develop predictive immunologic and virologic signatures of risk for viral diseases in patients receiving immunosuppressive agents. He primarily employs polychromatic flow cytometry to phenotypically and functionally describe subsets of the protective immune system.

Achievements

2002 Podilarian Award, "recognizing commitment, leadership, and strong advocacy on the part of patients and fellow students," University of Oklahoma College of Medicine.

2003 Robert C. Lawson Award, presented by the senior class "To the medical student who has demonstrated exceptional humane qualities during training," University of Oklahoma College of Medicine.
2003 Humanitarianism in Medicine Award, awarded by the faculty "To the student showing the greatest promise through commitment to the scholarly acquisition of and effective application of knowledge and who has gained the complete respect of peers with high standards in integrity, compassion, and dedication to the practice of medicine," University of Oklahoma College of Medicine.

2005 Resident Achievement Award, "For Outstanding Achievement as a PGY-2 Resident," Emory University Department of Medicine.

2006 Ambulatory Clinic Physician Award, Spring. Emory University Department of Medicine.

2006 Resident Achievement Award, "For Outstanding Achievement as a PGY-3 Resident," Emory University Department of Medicine.

2007 J Willis Hurst Fellow Teaching Award, "For Excellence in Teaching by a Subspecialty Fellow," Emory University Department of Medicine.

2012 Outstanding Attending Award, Emory University Hospital Pharmacy Residency Program, Emory School of Medicine

Associations

American Medical Association

American College of Physicians

Infectious Diseases Society of America

International Society of Infectious Diseases

American Society of Transplantation Infectious Disease Community of Practice

Transplant Infectious Disease Section of The Transplant Society

Publications

Peer Reviewed Manuscripts

JT Jacob, AK Mehta, MK Leonard. Acute Forms of Tuberculosis in Adults. The American Journal of Medicine. 122(1):12-7, 2009 Jan.

AK Mehta, AA Langston. Use of posaconazole in the treatment of invasive fungal infections. Expert Reviews in Hematology. 2(6):619-30, 2009 Dec.

Mehta AK, Halvosa JS, Gould CV, Steinberg JP. The Efficacy of Alcohol-Based Hand Rubs in the Disinfection of Stethoscopes. Infection Control and Hospital Epidemiology 2010; 31: 870–872.

Anderson AM, Mehta AK, Wang YF, Jing Q, Easley K, Nguyen ML. HIV-associated histoplasmosis in a nonendemic area of the United States during the HAART era: role of migration from endemic areas and lack of antiretroviral therapy. J Int Assoc Physicians AIDS Care (Chic). 2010 Sep-Oct;9(5):296-300.

AK Mehta, GM Lyon. Infectious Diseases in End Stage Liver Disease Patients. Crit Care Nurs Clin North Am. 2010 Sep;22(3):291-307.

Lo DJ, Weaver TA, Stempora L, Mehta AK, Ford ML, Larsen CP, Kirk AD. Selective Targeting of Human Alloresponsive CD8(+) Effector Memory T Cells Based on CD2 Expression. Am J Transplant. 2011 Jan;11(1):22-33.

Wrammert J, Koutsonanos D, Li G-M, Edupuganti S, Sui J, Morrissey M, McCausland M, Skountzou I, Hornig M, Lipkin WI, Mehta A, Razavi B, Del Rio C, Zheng N-Y, Lee J-H, Huang, Z Ali, K Kaur, S Andrews, RR Amara, Y Wang, SR Das, CD O’Donnell, JW Yewdell M, Subbarao K, Marasco WA, Mulligan MJ, Compans R, Ahmed R, and Wilson PC. Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection. J Exp Med 2011 Jan;208(1):181-193.

Edupuganti S, Rouphael N, Mehta A, Eaton M, Heller JG, Bressler A, Brandt M, O'Donnell K. Fusarium falciforme Vertebral Abscess and Osteomyelitis: Case Report and Molecular Classification. J Clin Microbiol. 2011 Jun;49(6):2350-3.

Nakaya HI, Wrammert J, Lee EK, Racioppi L, Marie-Kunze S, Haining WN, Means AR, Kasturi SP, Khan N, Li GM, McCausland M, Kanchan V, Kokko KE, Li S, Elbein R, Mehta AK, Aderem A, Subbarao K, Ahmed R, Pulendran B. Systems biology of vaccination for seasonal influenza in humans. Nat Immunol. 2011 Jul;12(8):786-95. PMCID: PMC3140559.

AK Mehta, R Moracco-Friedman, GM Lyon III. Vaccination in solid organ transplant recipients. Journal of the Medical Association of Atlanta. 2012 Feb; 84(1): 24-31.

Li, GM; Chiu, C; Wrammert, J ; McCausland, M; Andrews, SF; Zheng, NY; Lee, JH; Huang, M; Qu, XY; Edupuganti, S; Mulligan, M; Das, SR; Yewdell, JW; Mehta, AK; Wilson, PC; Ahmed, R. Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells. Proc Nat Acad Sci USA. 2012 Jun;109(23):9047-9052.

Glotz D, Chapman JR, Dharnidharka VR, Hanto DW, Castro MCR, Hirsch HH, Leblond V, Mehta AK, Moulin B, Pagliuca A, Pascual J, Rickinson AB, Russo FR, Trappe RU, Webster AC, Zuckermann AO, and Gross TG. The Seville global consensus workshop for progress in post-transplant lymphoproliferative disorders. Transplantation. 2012 Oct 27;94(8):784-93.

J Guarner, WS Armstrong, SW Satola, AK Mehta, R Jerris, J Hilinski, EM Burd, CS Kraft and CA del Rio. Development, Implementation, and Evaluation of a 4th Year Medical School Elective Course in Clinical Microbiology Using Case-Based Vignettes. J Med Microbiol April 2013.

Onor IO, Todd SB, Meredith E, Perez SD, Mehta AK, Lyon GM, Knechtle SJ, Hanish SI. Evaluation of clinical outcomes of prophylactic versus preemptive cytomegalovirus strategy in liver transplant recipients. Transpl Int. 2013 Jun;26(6):592-600. PMID:23590709

Lo DJ, Farris AB, Song M, Leopardi F, Anderson DJ, Strobert EA, Ramakrishnan S, Turgeon NA, Mehta AK, Turnbull B, Maroni B, Violette SM, Kirk AD. Inhibition of αvβ6 Promotes Acute Renal Allograft Rejection in Nonhuman Primates. Am J Transplant. 2013 Oct 1

Koura DT, Horan JT, Langston AA, Qayed M, Mehta A, Khoury HJ, Harvey RD, Suessmuth Y, Couture C, Carr J, Grizzle A, Johnson HR, Cheeseman JA, Conger JA, Robertson J, Stempora L, Johnson BE, Garrett A, Kirk AD, Larsen CP, Waller EK, Kean LS. In Vivo T Cell Costimulation Blockade with Abatacept for Acute Graft-versus-Host Disease Prevention: A First-in-Disease Trial. Biol Blood Marrow Transplant. 2013 Nov;19(11):1638-49. PMID24047754

Krummey SM, Cheeseman JA, Conger JA, Jang PS, Mehta AK, Kirk AD, Larsen CP, Ford ML. High CTLA-4 Expression on Th17 Cells Results in Increased Sensitivity to CTLA-4 Coinhibition and Resistance to Belatacept. The American Journal of Transplantation. In press.

Friedman-Moraco RJ, Mehta AK, Lyon GM, Kraft CS. Fecal microbiota transplantation for refractory Clostridium difficile colitis in solid organ transplant recipients. Am J Transplant. 2014 Feb;14(2):477-80.

C Chiu, M McCausland, J Sidney, F-M Duh, N Rouphael, A Mehta, M Mulligan, M Carrington, A Weinberg, MJ Levin, B Pulendran, B Peters, A Sette and R Ahmed. Human CD8+ T cells that recognize an epitope conserved between alpha- and gamma-herpesviruses. PLoS Pathog. 2014 Mar 27;10(3):e1004008.

Xu H, Perez SD, Cheeseman J, Mehta AK, Kirk AD. The allo- and viral-specific immunosuppressive effect of belatacept, but not tacrolimus, attenuates with progressive T cell maturation. Am J Transplant. 2014 Feb;14(2):319-32.

Kirk AD, Guasch A, Xu H, Cheeseman J, Mead SI, Ghali A, Mehta AK, Wu D, Gebel H, Bray R, Horan J, Kean LS, Larsen CP, Pearson TC. Renal Transplantation Using Belatacept Without Maintenance Steroids or Calcineurin Inhibitors. Am J Transplant. 2014 Mar 31.

Book Chapters:

Aneesh K. Mehta. “Suggested Therapy of Clostridium Difficile Colitis after Transplantation,” in The AST Handbook of Transplant Infections (eds D. Kumar and A. Humar), Wiley-Blackwell, Oxford, UK. 2011.

Aneesh K. Mehta. “Post-Operative Monitoring: Protective Immune Competence” in Textbook of Organ Transplantation. Ed: Allan D. Kirk, Stuart J. Knechtle, Christian P. Larsen, Joren C. Madsen, Thomas C. Pearson, Steven B. Webber. In press.