David M. Guidot, MD
Title: Associate Professor of Pulmonary & Critical Care Medicine
Director, Emory Alcohol and Lung Biology Center and T32 Training Program
Research: The mechanisms by which chronic alcohol abuse renders the lung susceptible to acute injury, particularly in response to sepsis or other acute inflammatory insults. Specific facets including the role of angiotensin II in mediating ethanol-induced oxidative stress and alveolar epithelial cell dysfunction, and the potential efficacy of granulocyte/macrophage colony-stimulating factor (GM-CSF) treat ment for patients with alcohol abuse at high risk for acute lung injury.
The primary model used in his laboratory is the Lieber-DeCarli diet in Sprague-Dawley rats. However, newer projects are using ethanol-fed mice (with ethanol added to the drinking water) to take advantage of relevant transgenic constructs (such as GM-CSF under-expressing and over-expressing mice, as well as mice that express HIV-related proteins.
Contact Info: Atlanta VAMC (151-P)
1670 Clairmont Road
Decatur, GA 30033
404-321-6111, ext. 6935
dguidot@emory.edu