Jinhu Wang, PhD
Assistant Professor of Medicine
Emory University School of Medicine
Office: 315 Woodruff Memorial Building
Additional Contact Information
101 Woodruff Circle
Atlanta, Georgia 30322
Dr. Wang is an Assistant Professor in Emory University School of Medicine. He received his PhD in Developmental Biology in Chinese Academy of Science. he got his postdoctoral research training in Dr. Kenneth Poss’s Lab at Duke University. His broad research goal is to understand how regenerative responses to injury have been optimized in non-mammalian vertebrates like zebrafish, to discover new targets that underline the regenerative deficiencies in mammals.
In the past several years, his work was focused on investigating regenerative biology of two major adult cardiac tissues: the myocardium and the epicardium. Using a new Cre-loxP mediated myocardial ablation approach, he and his colleagues showed that depleting up to 60% of myofibers in adult zebrafish heart caused classic indicators of heart failure: gasping, lethargy and reduced exercise capacity. They found that adult zebrafish can fully regenerate lost myocardium and reverse the signs of heart failure within several days, through massive cardiomyocyte proliferation detected throughout the heart. Using a new bacterial nitroreductase ablation system, He and his colleagues demonstrated that the epicardium is required for heart regeneration. Furthermore, their work showed that the epicardium itself has high capacity for renewal and fully regenerates even after 90% loss of epicardial cells.
Honors and Rewards:
2015 – 2019 American Heart Association NCRP Winter 2015 Scientist Development Grant
2012 – 2013 American Heart Association MAA Spring 2012 Postdoctoral Fellowship
2010 – 2012 American Heart Association MAA Spring 2010 Postdoctoral Fellowship
Wang J. and Poss k.D. (2016) Methodologies for inducing cardiac injury and assaying regeneration in adult zebrafish. Methods Mol Biol, 1451:225-35.
Nagelberg D., Wang J., Su R., Torres-Vazquez J., Poss K.D. and Knaut H. (2015) Origin, specification and plasticity of the great vessels of the heart. Current Biology, 25, 2099–2110.
Wang J.*, Cao J.*, Dickson A.L., and Poss K.D. (2015) Regeneration of the ventricular epicardium is directed by the cardiac outflow tract and Hh signaling. Nature 522(7555): 226-30. *equal contribution.
Wang J., Karra R., Dickson A.L., and Poss K.D. (2013) Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration. Dev. Biol. 382(2): 427-435.
Wang J., Panáková D., Kikuchi K., Holdway J. E., Gemberling M., Burris J. S., Singh S.P., Dickson A.L., Lin Y. F., Sabeh Werdich A. A., Yelon D., MacRae C. A., and Poss K. D. (2011) The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion. Development 138(16): 3421-30.
Kikuchi K., Gupta V., Wang J., Holdway J. E., Wills A. A., Fang Y., and Poss K. D. (2011) tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration. Development 138(14): 2895-2902.