Publications:
Bibliography:
a. Published and accepted research articles (clinical, basic science, other) in refereed journals:
1. Burns CB, Taylor WR and Ingram RH Jr. Effects of deep inspiration in asthma: Relative airway and parenchymal hysteresis. J Appl Physiol 59:1590-1596, 1985.
2. Silverman HJ, Taylor WR, Smith PL, Sobotka A, Lichtenstein LM and Bleeker ER. Prevention of canine anaphylaxis with isoproterenol. Am Rev Respir Dis 134:243-249, 1986.
3. Silverman HJ, Taylor WR, Smith PL, Sobotka A, Permutt S, Lichenstein LM and Bleeker ER. Effect of antihistamines on the cardiopulmonary changes due to canine anaphylaxis. J Appl Physiol 64:210-217,1988.
4. Taylor WR and Alexander RW. Polar secretion of insulin-like growth factor-1 by cultured porcine aortic endothelial cells. J Cell Physiol 154:139-142, 1993.
5. Taylor WR and Alexander RW. Autocrine control of wound repair by insulin-like growth factor-1 in cultured endothelial cells. Am J Physiol 265 (Cell Physiol 34):C801-C805, 1993.
6. Frohwein S, Klein JL, Lane A and Taylor WR. Dobutamine stress transesophageal echocardiography in the diagnosis of coronary artery disease. J Am Coll Cardiol 25:823-829, 1995.
7. Howard A, Alexander RW and Taylor WR. Effects of magnesium on nitric oxide synthase activity. Am J Physiol (Cell Physiol 38:) C612-C618, 1995.
8. Montgomery DH, Ververis JJ, McGorisk G, Frohwein S, Martin RP and Taylor WR. Natural history of severe atheromatous disease of the thoracic aorta: A transesophageal echocardiographic study. J Am Col Cardiol 27:95-101, 1996.
9. Rubin J, Biskobing D, Fan, X, Rubin C, McLeod K and Taylor WR. Pressure regulates osteoclast formation and MCSF expression in marrow culture. J Cell Physiol 170:81-87, 1997.
10. Howard AH, Alexander RW, Lou P and Taylor WR. Cyclic deformation induces an oxidative stress in cultured endothelial cells. Am J Physiol 272 (Cell Physiol 41): C421-C427, 1997.
11. Fukui T, Ishazaka N, Rajagopalan S, Laursen JB, Capers Q, Taylor WR, Harrison DG, de Leon H, Wilcox J and Griendling KK. p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats. Circulation Research 80:45-51, 1997.
12. Capers Q, Bech Laursen J, Fukui T, Rajagopalan S, Mori I, Lou P, Freeman BA, Berrington WR, Griendling KK, Harrison DG, Runge MS, Alexander RW, and Taylor WR. Vascular thrombin receptor regulation in hypertensive rats. Circulation Research 80:838-844, 1997.
13. Cohn JN, Ziesche S, Smith R,. Anand I, Dunkman WB, Loeb H, Cintron G, Boden W, Baruch L, Rochin P, and Loss L, for the Vasodilator-Heart Failure Trial (V-HeFT) Study Group. Effect of the calcium antagonist felodipine as supplementary vasodilator therapy in patients with chronic heart failure treated with enalapril: V-HeFT III.Vasodilator-Heart Failure Trial. Circulation. 96(3):856-63, 1997.
14. Capers Q, Alexander RW, Lou P, deLeon H, Wilcox JN, Howard AB, Taylor WR. Monocyte chemoattractant protein-1 expression in aortic tissues of hypertensive rats. Hypertension 30:1397-1402, 1997.
15. Zafari AM, Ushio-Fukai M, Akers M, Yin Q, Shah A, Harrison DG, Taylor WR, Griendling KK. Novel role of NADH/NADPH oxidase-derived hydrogen peroxide in angiotensin II-induced hypertrophy of rat vascular smooth muscle cells. Hypertension 32:488-495, 1998.
16. Rubin J, Gray M, Taylor WR. Cellular deformation: mechanics and mechanisms of physiologic response: introduction to the Emory Symposium. American Journal of Medical Science 316:153-155, 1998.
17. Nerem RM, Alexander RW, Chappell DC, Medford RM, Varner SE, Taylor WR. The study of the influence of flow on vascular endothelial biology. American Journal of Medical Science 316:169-75, 1998.
18. Taylor WR. Mechanical deformation of the arterial wall in hypertension: a mechanism for vascular pathology. American Journal of Medical Science 316(3):156-160, 1999.
19. Kim, JG, Taylor, WR, and Parthasarathy, S. Demonstration of the presence of lipid peroxide-modified proteins in human atherosclerotic lesions using a novel lipid peroxide-modified anti-peptide antibody. Atherosclerosis 143:335-40, 1999.
20. Isaacs SD, Fax X, Fan D, Gewant H, Murphy TC, Farmer P, Taylor WR, Nanes MS, Rubin J. The role of NFkB in the regulation of macrophage colony stimulating factor by tumor necrosis factor-alpha in ST2 bone stromal cells. J Cell Physiology. Journal of Cellular Physiology 179:193-200, 1999.
21. Rubin J, Fan X, Biskobing DM, Taylor WR, Rubin CT. Osteoclastogenesis is Repressed by Mechanical Strain in an In Vitro Model. J Orthop Res, 1999; 17:639-645.
22. Taylor WR. Hypertensive Vascular Disease and Inflammation: Mechanical and Humoral Mechanisms. Current Hypertension Reports 1999; I:96-101.
23. Taylor WR and Davidoff MN. Management of Congestive Heart Failure Caused by Systolic Dysfunction: I. Hospital Physician Board Review Manual 1999;5:1-12.
24. Taylor WR and Mavromatis K. AIDS and the Cardiovascular System. Hospital Physician Board Review Manual 1999;5:1-12.
25. Taylor WR. Diseases of the Aorta. Hospital Physician Board Review Manual 1999;5:1-11.
26. De Keulenaer GW, Ushio-Fukai M, Yin Q, Chung AB, Lyons PR, Ishizaka N, Rengarajan K, Taylor WR, Alexander RW, Griendling KK. Convergence of redox-sensitive and mitogen activated protein kinase signaling pathways in TNF-a-mediated MCP-1 induction in vascular smooth muscle cells. Arterioscler, Thromb and Vascular Biol, 2000;20:385-391.
27. Wong M, Baruch L, Cohen I, Deedwania P, Perry G, Taylor WR, Lopez B. Felodipine as adjunctive therapy improves left ventricular emptying in patients with chronic heart failure treated with enalapril: Echocardiographic substudy of VHeFT III. J Cardiac Failure 2000:6(1):19-28.
28. Smith RF, Germanson T, Judd D, Wong M, Zieche S, Anand I, Taylor WR, Cohn JN for the V-Heft III Investigators. Plasma norepinephrine and atrial natriuretic peptide in heart failure: Influence of felodipine in the third vasodilator heart failure trial. J Cardiac Failure 2000:6(2):97-107.
29. Bush EL, Maeda N, Kuziel W, Dawson TC, Wilcox JN, Deleon H, and Taylor WR. CC Chemokine Receptor 2 is Required for Macrophage Infiltration and Vascular Hypertrophy in Angiotensin II-Induced Hypertension. Hypertension 2000; 36:360-363.
30. Lerakis S, Clements SD, Taylor WR, Robinson P, Martin RP. Transesophageal echocardiography detection of an esophageal sarcoma mimicking aortic dissection. J Am Soc Echocardiogr. 2000 Jun; 13(6):619-21.
31. Weiss D, Kools J, Taylor WR. Angiotensin II-induced hypertension accelerates the development of atherosclerosis in Apo E-deficient mice. Circulation 2001:103(3):448-454.
32. Goldschmidt ME, McLeod KJ, Taylor WR. Integrin-Mediated Mechanotransduction in Vascular Smooth Muscle Cells: Frequency and Force Response Characteristics. Circulation Research 2001:88:674-680.
33. Sakamoto H, Aikawa M, Hill CC, Weiss D, Taylor RW, Libby P, Lee RT. Biomechanical Strain Induces Class A Scavenger Receptor Expression in Human Monocyte/Macrophages and THP-1 Cells: A Potential Mechanism of Increased Atherosclerosis in Hypertension. Circulation 2001:104:109-114.
34. Sutliff RL, Dikalov S, Weiss D, Parker J, Raidel S, Racine AK, Russ R, Haaase CP, Taylor WR, and Lewis WL. Nucleoside Reverse Transcriptase Inhibitors Impair Endothelium-Dependent Relaxation by Increasing Superoxide. AJP 2002:DOI 10.1152.
35. Sorescu D, Weiss D, Lassègue B, Clempus RE, Szöcs KE, Sorescu GP, Valppu L, Quinn MT, Lambeth JD, Vega JD, Taylor WR, and Griendling KK. Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis. Circulation. 2002 Mar 26;105(12):1429-35.
36. Rubin J, Murphy TC, Fan X, Goldschmidt M, Taylor WR. Activation of extracellular signal-regulated kinase is involved in mechanical strain inhibition of RANKL expression in bone stromal cells. J Bone Miner Res. 2002 Aug;17(8):1452-60.
37. Sorescu GP, Sykes M, Weiss D, Platt MO, Saha A, Hwang J, Boyd NL, Boo YC, Vega JD, Taylor WR, Jo H. Bone morphogenic protein 4-produced in endothelial cells by oscillatory shear stress stimulates an inflammatory response. J Biol Chem. 2003 May 23
Review articles:
1. Griendling KK, Lassegue BP, Taylor WR and Alexander RW. Control of vascular tone by the endothelium: New Insights. J Crit Illness 1993:8(3):355-370.
2. Nerem RM, Harrison DG, Taylor WR and Alexander RW. Hemodynamics and vascular endothelial biology . J Cardiovasc Pharm 1993:(suppl):s6-s10.
3. Weiss D, Sorescu D, Taylor WR. Angiotensin II and Atherosclerosis. American Journal of Cardiology 2001:87;25C-32C.
4. Lerakis S, Taylor WR, Lynch M, Litman CM, Clements SD, Thompson TD, Martin RP. The role of transesophageal echocardiography in the diagnosis and management of patients with aortic perivalvular abscesses. Am J Med Sci. 2001 Feb;321(2):152-5
Book chapters:
1. Taylor, WR (Contributor). In JF Lutz, Hurst's The Heart, Pretest Self-assessment and Review, 1998, McGraw Hill, New York.
2. Taylor, WR and Mavromatis K (contributing author). AIDS and the Cardiovascular System, In: Hospital Physician Cardiology Board Review Manual, Volume 5, Part 1, 2-12, 1999.
3. Guest T and Taylor WR. Aspirin, antioxidants and other factors. In: W Branch , RW Alexander, RC Schlant and JW Hurst Editors. Cardiology in Primary Care. 2000, McGraw Hill, New York.
Grants:
Federally Funded Grants:
P.I. W. Robert Taylor
NIH RO1 HL70531
Biology, Biomechanics, and AtherosclerosisP.I. W. Robert Taylor
NIH RO1 DK059499-01
Vascular Inflammation and Advanced Glycation EndProductsP.I. W. Robert Taylor
NIH RO1 HL62820R01
Regulation of Osteopontin Expression by Mechanical StrainP.I. W. Robert Taylor
VA Merit Review Board
Vascular Matrix Components and M-CSF ExpressionP.I. David G. Harrison
NIH P01 HL58000
Molecular Control of Vascular Function by Oxidative StressP.I. W. Robert Taylor
Project III: Hypertension, Physical Forces, and Vascular InflammationP.I. David G. Harrison
Research Training in Academic Cardiology
NIH
Private Foundation Funded Grants:
P.I. W. Robert Taylor
Medtronic, Inc.
Development of a Large Animal Model of Abdominal Aneurysm FormationP.I. W. Robert Taylor
Sankyo Pharma
AIMS: The Atherosclerosis and Inflammatory Markers Study. A randomized, double-blind, placebo-controlled, parallel group, comparative study of olmesartan, an angiotensin receptor blocker, in patients with established atherosclerosis.P.I. W. Robert Taylor
Novartis Pharmaceuticals
VALUE TrialP.I. W. Robert Taylor
Smith Kline Beecham
Effects of Carvedilol on Endothelial Function in Humans
